Submitted: 24 Sep 2021
Revision: 02 May 2022
Accepted: 03 May 2022
ePublished: 08 Sep 2022
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Avicenna J Dent Res. 2022;14(3): 137-143.
doi: 10.34172/ajdr.2022.25
  Abstract View: 407
  PDF Download: 307

Review Article

Diagnostic Strategies for Early Detection of Oral Squamous Cell Carcinoma: A Review Article

Soussan Irani 1,2* ORCID logo

1 Associate Professor, Dental Research Centre, Oral Pathology Department, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran
2 Lecturer at Griffith University, Gold Coast, Australia
*Corresponding Author: Corresponding author: Soussan Irani, Tel:+98813- 8354250, Fax:+98813- 8354220, Email: sousanirani@gmail.com, , Email: Irani@umsha.ac.ir


Background: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer with high morbidity and mortality rates. Late diagnosis and high incidence rate of OSCC have become global healthcare issues. The purpose of this review was to provide an overview of the diagnostic and prognostic biomarkers in OSCC.

Methods: A literature search in PubMed, ScienceDirect, and Google Scholar was performed. The keywords “early detection”, “oral cancer”, and “oral squamous cell carcinoma” were searched in the title and abstract of the articles published in English from 2000 to mid-2021. The full texts of 250 articles were retrieved and only 63 articles met the inclusion criteria.

Results: In summary, all selected papers discussed the importance of early detection along with different factors and techniques to detect oral cancer. The biomarkers were divided into three groups as follows: salivary biomarkers, circulating biomarkers, and tissue biomarkers.

Conclusions: In this review article, salivary biomarkers along with the circulating and tissue biomarkers were reviewed. Besides, some detection techniques were explained.

Please cite this article as follows: Irani S. Diagnostic strategies for early detection of oral squamous cell carcinoma: a review article. Avicenna J Dent Res. 2022; 14(1):137-143. doi:10.34172/ajdr.2022.25
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