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Submitted: 01 Dec 2017
Accepted: 25 Mar 2018
ePublished: 15 Jun 2018
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Avicenna J Dent Res. 2018;10(2): 67-70.
doi: 10.34172/ajdr.2018.15
  Abstract View: 1086
  PDF Download: 801

Research Article

Mast Cells Density in Hyperkeratosis, Dysplastic Oral Mucosa and Oral Squamous Cell Carcinoma

Molouk Torabi 1,2 ORCID logo, Jahangir Haghani 1,2, Maryam Alsadat Hashemipour 1,2* ORCID logo, Mehdi Ebrahimi 3

1 Kerman Dental and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
2 Department of Oral and Maxillofacial Pathology, Dental School, Kerman University of Medical Science, Kerman, Iran.
3 Dentist, Dental School, Kerman University of Medical Science, Kerman, Iran.
*Corresponding Author: *Correspondence to Maryam Alsadat Hashemipour, Tel: +989132996183, Fax: 00983412118073, Email: m_s_hashemipour@yahoo.com

Abstract

Background: Mast cells normally present in small numbers in the connective tissue of all organs and release a variety of potent mediators like histamine, leukotrienes, cytokines, chymase, basic fibroblast growth factor (bFGF), tryptase and heparin through degranulation.

Objectives: The aim of the present study was the assessment of mast cell density in hyperkeratosis, dysplastic oral mucosa and oral squamous cell carcinoma (OSCC).Methods: In this retrospective analytical study, paraffinized specimens from 15 cases of normal mucosa and 23 cases of well-differentiated OSCC, cases of hyperkeratosis and dysplasia were selected. Sections were stained with toluidine blue and then were counted at 400× magnification in hotspot areas under a light microscope. The results were analyzed using ANOVA. P values less than 0.05 were considered significant.

Results: Mast cells density (MCD) increased in hyperkeratosis, dysplasia, and OSCC. There was not any significant correlation between mast cell density and hyperkeratosis, dysplastic mucosa and normal mucosa. There were significant differences between mast cell counts in SCC and normal mucosa.

Conclusions: MCD is higher in hyperkeratosis and dysplastic oral mucosa than in normal mucosa. There were significant differences between mast cell counts in SCC and normal mucosa.


Citation: Torabi M, Haghani J, Hashemipour MA, Ebrahimi M. Mast cells density in hyperkeratosis, dysplastic oral mucosa and oral squamous cell carcinoma. Avicenna J Dent Res. 2018;10(2):65-68. doi: 10.15171/ajdr.2018.15.
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