Submitted: 09 Aug 2014
Revised: 15 Dec 2018
Accepted: 01 Jan 2015
First published online: 20 Jun 2015
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Avicenna J Dent Res. 2015;7(1):4-4.
doi: 10.17795/ajdr-22656
  Abstract View: 76
  PDF Download: 239

Research Article

An in Vitro Study on the Antibacterial Effect of Ferula Assa-Foetida L. and Quercus Infectoria Olivier Extracts on Streptococcus Mutans and Streptococcus Sanguis

Mohammad Mehdi Fani 1, Abdollah Bazargani 2, Mohammad Ali Farboodniay Jahromi 3, Zahra Hasanpour 4, Khosrow Zamani 2, Ehsan Yousefi Manesh 5 *

1 Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Genetics, Faculty of Science, Shahrekord University, Shahrekord, IR Iran
5 Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IR Iran
*Corresponding author: Ehsan Yousefi Manesh, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7136263192, Fax: +98-7136270325, E-mail: Email: ehsanyousefimanesh@yahoo.com

Article

Background: From the ancient times, medicinal herbs have been regarded as efficient resources for the treatment of diseases. Among the diseases that can be treated by medicinal herbs, infectious diseases like oral ones are of notable importance.

Objectives: The aim of this study was to evaluate the antibacterial effects of Ferula assa-foetida L (F. assa-foetida L.) and Quercus infectoria Olivier (Q. infectoria Olivier) aqueous and ethanolic extracts on Streptococcus mutans (S. mutans) and Streptococcus sanguis (S. sanguis).

Materials and Methods: The studied plants were F. assa-foetida L. and Q infectoria Olivier. Their extracts with different concentrations of 100, 50, 25, 12.5, 6.25, and 3.125 mg/mL were prepared in culture medium, with well diffusion method, and, for control, their antibacterial effects were compared with chlorhexidine. For each extract, the antibacterial ability was determined based on the created inhibition zone diameter in the microbial culture medium.

Results: The aqueous and ethanolic extract of F. assa-foetida L. lacked the inhibitory effect against the growth of S. mutans and S. sanguis bacteria. There was a significant difference among the inhibitory zones created by dissimilar concentrations of Q. infectoria (P = 0.025). Also, the aqueous and ethanolic extracts’ minimum inhibitory concentration (MIC) for S. mutans bacterium was calculated to be 12.5 mg/ mL, while its value for S. sanguis bacterium was 6.25 mg/mL.

Conclusions: The results of our study, regarding the observed effects based on differences in concentrations, suggest that further and more comprehensive studies should be undertaken to determine the appropriate concentration for obtaining the effect of the extract of F. assa-foetida L. and Q infectoria Olivier on S. mutans and S. sanguis

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