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Submitted: 01 Jun 2020
Accepted: 18 Jun 2020
ePublished: 30 Jun 2020
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Avicenna J Dent Res. 2020;12(2): 35-39.
doi: 10.34172/ajdr.2020.08
  Abstract View: 1334
  PDF Download: 1064

Original Article

The Effects of the Grape Seed Extract on Streptococcus mutans and Candida albicans: An In Vitro Study

Masoumeh Aslanimehr 1 ORCID logo, Ashraf Alizadeh 2, Faezeh Azmoudeh 3* ORCID logo

1 Associate Professor, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
2 General Dentist, Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
3 Assistant Professor of Oral and Maxillofacial Pathology, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
*Corresponding Author: Correspondence to Faezeh Azmoudeh, Tel: +98 28 33353064, Fax: +98 28 33353066; Email: , Email: fa.azmoodeh@gmail.com

Abstract

Background: Oral pathogens can affect a large population and the general health of individuals. Based on the evidence, the grape seed extract (GSE) contains herbal compounds that have the ability tosuppress oral pathogens associated with caries and fungal diseases. In this regard, the current studyaimed at evaluating the effect of GSE on Streptococcus mutans and Candida albicans.

Methods: The grape (Vitis vinifera L.) seed was used in this in-vitro experimental study. After thepreparation of methanolic GSE, its effect on S. mutans and C. albicans was assessed at 0.25-256 mg/mL concentrations. Then, the minimum inhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) were determined by macro broth dilution methods. Finally, data were analyzedby SPSS, version 20.

Results: The results showed that GSE inhibits the growth of S. mutans and C. albicans. In addition, theMIC and MBC of the extract against S. mutans and C. albicans were 2 and 8 mg/mL, as well as 32 and64 mg/mL, respectively.

Conclusions: In general, GSE had a significant antimicrobial effect on S. mutans, while it only affected C. albicans at high concentrations.


Citation: Aslanimehr M, Alizadeh A, Azmoudeh F. The effects of the grape seed extract on Streptococcus mutans and Candida albicans: An In Vitro Study. Avicenna J Dent Res. 2020;12(2):35-39. doi: 10.34172/ajdr.2020.08.
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