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Submitted: 16 Feb 2019
Accepted: 25 Mar 2019
ePublished: 30 Mar 2019
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Avicenna J Dent Res. 2019;11(1): 1-7.
doi: 10.34172/ajdr.2019.01
  Abstract View: 1595
  PDF Download: 1174

Original Article

Non-surgical Periodontal Therapy With Adjunctive Topical Metronidazole + Piroxicam Gel Compared With Piroxicam Gel in the Treatment of Chronic Periodontitis

Amirhossein Farahmand 1 ORCID logo, Ferena Sayar 2* ORCID logo, Mona Ghourbani 3, Bahareh Jafarzadeh Esfahani 3, Ali Ghanbarzadeh 3, Amirreza Shirazi 3

1 Assistant Professor, Department of Periodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
2 Associate Professor, Department of Periodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
3 Dentists (private practice).
*Corresponding Author: Email: sayar_ferna@yahoo.com

Abstract

Background: Host modulation therapy represents a treatment concept in which drug therapies are applied as an adjunctive therapy to conventional periodontal treatments to counteract the destructive effects of the host inflammatory response.

Methods: This is a randomized split-mouth clinical trial in which a total of 40 outpatients diagnosed with mild-moderate chronic periodontitis with at least two pairs of contralateral anatomically matching proximal tooth surfaces showing probing depth of ≥5 mm were enrolled. Full-mouth scaling and root planing (SRP) was performed for all patients and pockets larger than 5 mm were selected for application of the studied gels. The selected sites were randomly divided into group A (piroxicam + metronidazole) and group B (piroxicam). Recall appointments were scheduled every two weeks within 3 months. The periodontal parameters, assessed in the molar teeth, also recorded that changes in clinical parameters during the study.

Results: A total of 34 patients, with mean age of 45.2±8.6 (range 32-60) years, none of whom developed unpleasant side effect, were enrolled. Plaque index was significantly higher in group A; further it was a statistically significant difference in Bleeding on probing levels in group A at the baseline to last interval recall while current study. The results exhibited significant reductions in pocket depth within 3 months when compared to the baseline values, while the combination adjunctive therapy was more effective to reduce pocket depth. Furthermore, both groups showed a statistically significant mean reduction in clinical attachment level (CAL), but in the test group A had a higher CAL gain than in the control group B (P=0.039).

Conclusions: The use of a combination of drugs can help reduce the clinical signs of periodontal disease, therefore, by changing the patient’s health habits along with periodontal treatment, the mechanical treatment that a microbial plaque can be obtained, and then the use of piroxicam + metronidazole gel as a complementary therapy, the recovery process can be accelerated.


Citation: Farahmand A, Sayar F, Ghourbani M, Jafarzadeh Esfahani B, Ghanbarzadeh A, Shirazi A. Non-surgical periodontal therapy with adjunctive topical metronidazole + piroxicam gel compared with piroxicam gel in the treatment of chronic periodontitis. Avicenna J Dent Res. 2019;11(1):1-7. doi: 10.15171/ajdr.2019.01.
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