In vivo condition in bone tissue engineering: A review article

Abstract

Context: Bone tissue engineering (BTE) aims to create functional bone substitutes that can repair or regenerate damaged bone tissue. Achieving this goal requires a deep understanding of the in vivo conditions under which natural bone develops, heals, and remodels. These conditions are complex and involve mechanical, biochemical, and cellular factors that govern bone formation and regeneration. Evidence Acquisition: This article discusses the key aspects of in vivo conditions that are essential for successful bone tissue engineering, including mechanical forces, biochemical signaling, cellular interactions, vascularization, immune responses, and the role of bone remodeling. Result: Understanding these factors is crucial for designing engineered bone constructs that can mimic native bone and function effectively in clinical applications. Conclusion: Ultimately, the continued refinement of in vivo models and a deeper understanding of the tissue microenvironment are essential for the development of bone tissue engineering therapies that are not only effective but also safe, sustainable, and capable of providing long-term functional outcomes for patients.

Keywords: Bone, tissue engineering, In vivo condition, Osteogenesis, Bone remodeling