Azam Valian
, Amir Ghasemi, Shahin Kasraei, Kiana Shakeri, Farzaneh Sadeghi Mahounak
* , Elham Zanguei
Abstract
In this systematic review and meta-analysis, we intended to determine whether increasing the application time of self-etch adhesives and universal adhesives could increase the bond strength between composite resin and enamel/dentin. Electronic databases i.e. MEDLINE via PubMed, ISI (Web of Science), and Scopus, were searched based on the PICOS strategy in order to gather in-vitro articles in English with no publication year limit. studies assessing the bond strength between enamel/dentin and composite resin through use of self-etch or universal adhesives were selected and further evaluated. Meta-analysis was performed using a random-effect model to determine the difference in bond value between the specimens that underwent longer adhesive application and the control groups. Amongst 352 gathered studies, 52 were selected for full-text analysis and 26 were chosen for inclusion in this review. 14 studies were included in the meta-analysis and a random-model effect was used for all but one analysis dependent on the heterogeneity percentage. The meta-analysis showed a significant increase in bond strength subsequent to increasing the application time of the aforementioned bonding systems to an extent. Doubling the application time increased the bond strength to both enamel and dentin however, tripling the application time seemed to be only beneficial to bond strength between enamel/dentin and self-etch/universal adhesive systems. The one-component adhesive systems were more impacted by the increased application time than two-component systems, however not enough data existed on the effect of adhesive systems pH level on bond strength value to gather a reach conclusion. Under the limitations of this review, it was concluded that increasing the application time of self-etch and universal adhesives to a certain extent, could increase bond strength to both ground dentin and enamel, under invitro conditions.