Abstract
Background: So many people worldwide have chronic periodontitis. Chemotherapeutic agents can
reduce host responses to bacterial pathogens and as a result reduce bone loss.
Objectives: The aim of this study was to compare the effect of antibiotics such as amoxicillin and
metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP)
in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic
periodontitis.
Methods: In this randomized double-blinded placebo-controlled clinical trials, 45 patients with
chronic moderate to severe periodontitis were randomly divided into 3 groups: the control group which
received SRP plus placebo, the test 1 group which received SRP plus AMX+MTZ, and the test 2 group
which received SRP plus CPF. PD and CAL were measured in each group at 3 time points (baseline, 1
month and 3 months after SRP). Statistical analysis was done using a paired t test and ANOVA.
Results: Mean PD and CAL in the test groups were compared to the control group and no significant
changes were found (P<0.05). Most changes in PD and CAL were seen at one month after intervention.
Better outcomes were seen in the test groups (test 2 better than test 1).
Conclusions: AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any
significant impact on reducing PD and CAL over one 1 and 3 months after treatment in patients with
chronic periodontitis.