Nishanthi Raja
* 
, Anuradha G, Swathi K.V, Krithika Chandrasekar Chandrasekar Lakshmi
Abstract
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common cancer types worldwide. Due to the limited availability of biomarkers and therapeutic targets it is the major leading causes of cancer death. There have been many studies conducted to show the role of autophagy related marker in cell survival and in the progression of several cancers, but it is unclear that autophagy related biomarker could be a marker in tumorigenesis and prognosis in OSCC. AIM: The aim of this review was to evaluate the available evidence about the autophagy related genes in oral squamous cell carcinoma possible role on tumorigenesis and prognostic significance in OSCC. Materials and Methods: A Systematic Review was conducted according to PRISMA statement, PICOS question was “Can autophagy genes be a marker in tumorigenesis and prognosis in oral cancer”.A search strategy was elaborated to retrieve studies applied on various data base PubMed, Google scholar, Cochrane Library, and Web of Science for five years (2018-2023). Risk of bias assessment was done using Quadas tool in Cochrane Rev-man software 5.4. Results: Three studies were included in this systematic review out of the total 178 studies that were found through the search, after being eliminated based on inclusion and exclusion criteria. The majority of the studies that were found accurately showed features of the tumor with a worse prognosis in OSCC that were associated to an autophagy-related biomarker. Conclusion: According to the review, investigations of biomarkers related to autophagy shows that they can be used to predict the diagnosis and prognosis of OSCC.