Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 6 2 2014 12 25 Barrier Membrane, a Device for Regeneration: Properties and Applications 53 57 10.17795/ajdr-21343 EN Sara Soheilifar Sepideh Soheilifar Mohsen Bidgoli Parviz Torkzaban REVIEW 10.17795/ajdr-21343 2014 06 18 2014 07 19 Context: This article reviews the available evidence about the barrier membranes utilized in Guided Tissue Regeneration process to prevent the migration of unfavorable cells to the wound area. Evidence Acquisition: Available evidence about membranes properties and their different uses were reviewed, and the results of clinical and animal studies and systematic reviews were gathered. Results: A large number of existing membranes with different features and compositions may lead to different study results; none of the available membranes can result in %100 predictable outcomes. Conclusions: Effectiveness of membranes in treating intrabony defects is very controversial; however, treating furcation defects using membranes was reported to be successful in a large number of studies.