Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 10 1 2018 03 01 Comparison the Effect of Ciprofloxacin Versus Amoxicillin and Metronidazole as an Adjunctive Therapy to Full Mouth Scaling and Root Planing of Chronic Periodontitis 11 15 10.34172/ajdr.2018.03 EN Janet Moradi Haghgoo Parviz Torkzaban Nazli Rabienejad https://orcid.org/0000-0003-2176-9786 Journal Article 10.34172/ajdr.2018.03 2017 12 06 2018 02 23 Background: So many people worldwide have chronic periodontitis. Chemotherapeutic agents can reduce host responses to bacterial pathogens and as a result reduce bone loss. Objectives: The aim of this study was to compare the effect of antibiotics such as amoxicillin and metronidazole (AMX+MTZ) with ciprofloxacin (CPF) as an adjunct to scaling and root planing (SRP) in pocket depth (PD) and clinical attachment loss (CAL) in patients with moderate to severe chronic periodontitis. Methods: In this randomized double-blinded placebo-controlled clinical trials, 45 patients with chronic moderate to severe periodontitis were randomly divided into 3 groups: the control group which received SRP plus placebo, the test 1 group which received SRP plus AMX+MTZ, and the test 2 group which received SRP plus CPF. PD and CAL were measured in each group at 3 time points (baseline, 1 month and 3 months after SRP). Statistical analysis was done using a paired t test and ANOVA. Results: Mean PD and CAL in the test groups were compared to the control group and no significant changes were found (P<0.05). Most changes in PD and CAL were seen at one month after intervention. Better outcomes were seen in the test groups (test 2 better than test 1). Conclusions: AMX+MTZ or CPF as an adjunct to SRP had better outcomes but did not have any significant impact on reducing PD and CAL over one 1 and 3 months after treatment in patients with chronic periodontitis.