Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 15 3 2023 09 30 Eruption of an Uncommon Impacted Mandibular Canine in a Large Inflamed Dentigerous Cyst With the Combined Marsupialization and Orthodontic Treatment: A Case Report 138 141 10.34172/ajdr.2023.1723 EN Vahid Mollabashi https://orcid.org/0000-0002-8450-7604 Hana Salehisaheb Hamid Naderi https://orcid.org/0000-0001-6936-5686 Nafiseh Shamloo Faezeh Yousefi Journal Article 10.34172/ajdr.2023.1723 2023 04 07 2023 04 24 A dentigerous cyst is a benign and asymptomatic lesion that may become extremely large and then interfere with tooth eruption. Marsupialization is known as the best treatment option for large cysts involving an unerupted permanent tooth. A 16-year-old female has been referred with the chief complaint of an unerupted tooth, extraoral and intraoral swelling, and pain. Radiographic examination demonstrated a unilocular, well-defined, and large radiolucent lesion extended from the distal of the right mandibular canine approximately to the left first mandibular molar. The mandibular left canine was also embedded within the lesion. The selected treatment plan was marsupialization, followed by performing orthodontic treatment of the unerupted mandibular canine. This clinical report presented the successful eruption of an impacted mandibular canine over a 4-years follow-up. The findings of this study revealed that the combination of marsupialization and orthodontic treatment is an effective treatment for large jaw cysts with impacted teeth.