Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 15 4 2023 12 29 Oral Manifestations of Aplastic Anemia: A Case Report 189 191 10.34172/ajdr.1679 EN Morad Hedayati Panah https://orcid.org/0000-0003-1459-0964 Leila Shahsavand Baghdadi Saeedeh Fatholahi https://orcid.org/0000-0002-7622-5463 Journal Article 10.34172/ajdr.1679 2023 01 13 2023 06 13 Aplastic anemia (AA) is a rare disease characterized by pancytopenia, susceptibility to infection, and difficulty maintaining hemostasis. Drugs are considered to be one of the most important risk factors associated with AA. Various studies have identified the pharmaceutical agents that may contribute to the development of AA. It is common for patients with severe periodontal disease and AA to experience spontaneous bleeding during brushing in terms of thrombocytopenia, which may further exacerbate dental problems. AA patients require comprehensive periodontal treatment that necessitates collaboration with a hematologist.