Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 1 1 2009 06 30 Orofacial Granulomatosis of the Upper Lip: A Case Report 37 40 EN F. Ahmadi Motemayel HR. Abdolsamadi S. Irani R. Bardal Journal Article Orofacial granulomatosis(OFG) is a granulomatous disease of the orofacial region which appears usually as a persistent and/or recurrent labial soft tissues swelling in the orofacial region and is characterized histologically by a granulomatous inflammation. OFG may cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. The etiology of oral lesions with non-caseating granulomas includes oral Crohn’s tooth associated infections, sarcoidosis and food or contact allergies. Treatment of OFG is not always necessary, although most patients do require some medical intervention.