Hamadan University of Medical Sciences Avicenna Journal of Dental Research 2423-7582 7 2 2015 12 01 Exfoliative Cheilitis: A Case Report 1 1 10.17795/ajdr-24943 EN Yasamin Barakian Mohammad Vahedi Parastoo Sadr Journal Article 10.17795/ajdr-24943 2014 10 28 2015 01 17 Introduction: Exfoliative Cheilitis (EC) is a rare chronic inflammatory condition affecting the vermillion border of the lips and characterized by excessive production of keratin. In this paper, a case of chronic EC that was relatively resistant to usual treatment is to be introduced. Also, we explain its clinical course and treatment procedures and measures. Case Presentation: We report a 25-year-old Iranian woman presented with desquamation of her lips. History, clinical feature and histopathological examination revealed a diagnosis of EC. Conclusions: Although treatment of EC in the present study had considerable success in the short-term follow-up, it should be noted, due to the unknown of the exact cause, no specific treatment or protocol has still been identified.