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Submitted: 02 Mar 2013
Revision: 27 Apr 2013
Accepted: 01 Jun 2013
ePublished: 25 Jun 2013
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Avicenna J Dent Res. 2013;5(1): 1-4.
doi: 10.17795/ajdr-20187
  Abstract View: 1083
  PDF Download: 480

Research Article

Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus

Seyed Javad Kia 1, Arash Mansourian 2*, Masoumeh Nikkhah 3, Nariman Nikparto 4, Najmeh Shanbezadeh 3

1 Department of Oral Medicine, Guilan University of Medical Sciences, Rasht, IR Iran
2 Department of Oral Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
3 Dentist, Private Practice, Tehran, IR Iran
4 Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
*Corresponding Author: Corresponding author: Arash Mansourian, Department of Oral Medicine, Tehran University of Medical Sciences, Tehran, IR Iran. Tel: +98-9123344090, Fax: + 98-2188497416, Email: Amansourian@tums.ac.ir

Abstract

Background: Lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. Immune dysregulation in the pathogenesis of oral lichen planus (OLP) is well-known phenomenon.

Objectives: In this study, we compared the levels of the peripheral blood T lymphocytes between patients with OLP and control group.

Patients and Methods: In this study, 32 and 16 patients respectively with and without OLP were recruited. Five milliliters of the participants' peripheral venous blood was drew in an EDTA-containing test tube and the levels of CD3+, CD4+, and CD8+ cells, CD4+/CD8+ and CD4+/ CD3+ ratio were measured by means of two-color flow cytometry. The data were analyzed in SPPS v.19 by employing Mann-Whitney U test.

Results: There were no significant difference among the levels of CD3+, CD4+, and CD8+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes between patients and control group; however, there was a significant difference between male and female patients with respect to the levels of CD3+ and CD4+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes.

Conclusions: Our results confirm that only local immune mechanism known as skin-associated lymphoid tissue, not a systemic immunologic disorder, was involved in the OLP.

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