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Submitted: 03 Dec 2020
Accepted: 20 Dec 2020
ePublished: 30 Dec 2020
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Avicenna J Dent Res. 2020;12(4): 126-130.
doi: 10.34172/ajdr.2020.25
  Abstract View: 85
  PDF Download: 63

Original Article

Comparison of the Salivary Levels of Homocysteine and C-Reactive Protein in Type 1 Diabetic Patients and Healthy Individuals

Mina Jazaeri 1 ORCID logo, Hamidreza Abdolsamadi 2 ORCID logo, Maryam Foroozandeh 3* ORCID logo, Zahra Razavi 4 ORCID logo, Alireza Soltanian 5 ORCID logo, Mehrdad Hajilooi 6 ORCID logo

1 Assistant Professor of Oral Medicine Department, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
2 Professor of Oral Medicine Department School of Dentistry, Hamadan University of medical sciences, Hamadan, Iran.
3 Assistant Professor, Department of Oral and Maxillofacial Radiology, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
4 Professor of Pediatric Endocrinology and Metabolism, Department of Pediatrics, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
5 Professor of Biostatistics Department of Biostatistics, School of Health Modeling of Non-communicable Diseases Research Center Health Sciences and Technology Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
6 Associate Professor of Medical Immunology, Department of Immunology, School of Medicine, Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
*Correspondence to Maryam Foroozandeh, Zip code: 6516647447. Tel: +98-9184400791, Fax: +98-813-8251885; Email: drforoozandeh1991@ yahoo.com

Abstract


Background: Diabetes mellitus type 1 (DM-1) is associated with pancreatic beta-cell destruction, inflammatory processes, and cardiovascular disorders. C-reactive protein (CRP) and homocysteine are considered as inflammatory processes and cardiovascular disorder indicators that can be used for monitoring patients with DM-1. The present study aimed to compare the salivary levels of homocysteine and CRP of DM-1 patients with those of healthy people.

Methods: In this case-control study, 82 patients participated, including 41 DM-1 patients (case group) and 41 healthy people (control group). The case and control groups were matched in terms of age, gender, and body mass index, and 5 mL of the saliva was collected from each participant. Then, the salivary levels of CRP and homocysteine were measured for each patient. Finally, several parameters were recorded for diabetic patients, including fasting blood glucose (FBS), 2-hour postprandial glucose (2hpp), and glycosylated hemoglobin (HbA1c), as well as the duration of the disease and the type and amount of insulin injections. Eventually, data were analyzed by SPSS software using descriptive statistics, independent t-test, and Pearson correlation coefficient.

Results: The salivary CRP and homocysteine concentration had no significant difference between patients and controls (P>0.05). There was no significant correlation between the salivary level of homocysteine and CRP and FBS, 2hpp, HbA1c, albuminuria, duration of disease, type and amount of insulin injection (P<0.05).

Conclusions: According to the results of the current study, the measurement of the salivary levels of CRP and homocysteine could not be helpful for monitoring patients with DM-1.


Keywords: Salivary biomarker, C-reactive protein, Homocysteine, Diabetes mellitus
Citation: Jazayeri M, Abdolsamadi H, Foroozandeh M, Razavi Z, Soltanian A, Hajilooi M. Comparison of the salivary levels of homocysteine and c-reactive protein in type 1 diabetic patients and healthy individuals. Avicenna J Dent Res. 2020;12(4):126-130. doi: 10.34172/ajdr.2020.25.
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